CK-PAN - Pan Cytokeratin

Control typePositive tissue control
High expression level
Positive tissue control
Low expression levels
Negative tissue control
TissueTonsilLiverTonsil
Description

Virtually all squamous epithelial cells must show a moderate to strong, distinct cytoplasmic staining reaction (Demonstration of CK-HMW).

Virtually all hepatocytes must show an at least weak to moderate cytoplasmic staining reaction typically with a membrane accentuation (Demonstration of CK LMW). 

 

Note epithelial cells of bile ducts will show a strong cytoplasmic staining reaction and cannot be used to evaluate analytical sensitivity (Demonstration of CK-LMW).

No staining reaction in lymphocytes.

 

Note interstitial/interdigitating reticulum cells may show a weak to moderate cytoplasmic staining reaction due to expression of CK 8 and 18.

Example

Virtually all squamous epithelial cells must show a moderate to strong, distinct cytoplasmic staining reaction (Demonstration of CK-HMW).

Virtually all hepatocytes must show an at least weak to moderate cytoplasmic staining reaction typically with a membrane accentuation (Demonstration of CK LMW). 

 

Note epithelial cells of bile ducts will show a strong cytoplasmic staining reaction and cannot be used to evaluate analytical sensitivity (Demonstration of CK-LMW).

No staining reaction in lymphocytes.

 

Note interstitial/interdigitating reticulum cells may show a weak to moderate cytoplasmic staining reaction due to expression of CK 8 and 18.