Multifunctional transcription factor.
+: >90% positive, +/-: 50-90% positive, -/+: 10 - >50% positive, -(+): 1-<10% positive, -: <1% positive, ?: conflicting evidence or insufficient information.
Lobular breast carcinoma (100%), yolk sac tumour and choriocarcinoma (100%)
Estrogen receptor or HER2 positive ductal breast carcinoma (estrogen receptor and HER2 positive ~90%, triple negative ~60%), urothelial carcinoma and squamous cell carcinoma of skin (~80%), malignant mesothelioma (~60%), chromophobic renal cell carcinoma (~50%)
Salivary gland carcinomas (~40%), pancreas adenocarcinoma (~40%?), squamous cell carcinoma of uterine cervix (~30%), larynx (~20%), and lung (~10%)
Adenocarcinomas of stomach, colon, prostate, endometrium (<10%), various sarcomas.
Adenocarcinomas apart from the above mentioned, endocrine tumours.
Identification of breast carcinoma and urothelial carcinoma.
Kidney and tonsil is recommended as positive and negative tissue controls for GATA3. In kidney, moderate
to strong nuclear staining reaction in virtually all epithelial cells lining the collecting ducts and podocytes in
glomeruli must be seen. In tonsil the vast majority of T-cells in the T-zones must show an at least weak
but distinct nuclear staining reaction. No staining of B-cells should be seen (dispersed intra-germinal Tcells
will be identified).
26.07.15 - MV/LE