GATA3

Assessments
Characteristics

Multifunctional transcription factor.

Neoplasms

+: >90% positive, +/-: 50-90% positive, -/+: 10 - >50% positive, -(+): 1-<10% positive, -: <1% positive, ?: conflicting evidence or insufficient information. + Lobular breast carcinoma (100%), yolk sac tumour and choriocarcinoma (100%) +/- Estrogen receptor or HER2 positive ductal breast carcinoma (estrogen receptor and HER2 positive ~90%, triple negative ~60%), urothelial carcinoma and squamous cell carcinoma of skin (~80%), malignant mesothelioma (~60%), chromophobic renal cell carcinoma (~50%) -/+ Salivary gland carcinomas (~40%), pancreas adenocarcinoma (~40%?), squamous cell carcinoma of uterine cervix (~30%), larynx (~20%), and lung (~10%) -(+) Adenocarcinomas of stomach, colon, prostate, endometrium (<10%), various sarcomas. - Adenocarcinomas apart from the above mentioned, endocrine tumours.

Application

Identification of breast carcinoma and urothelial carcinoma.

Controls

Kidney and tonsil are recommended as positive and negative tissue controls for GATA3. In kidney, moderate to strong nuclear staining reaction in virtually all epithelial cells lining the collecting ducts and podocytes in glomeruli must be seen. In the tonsil the vast majority of T helper cells (Th2) in the T-zones must show an at least moderate but distinct nuclear staining reaction. No staining of B-cells should be seen.

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