C-MYC

Characteristics

Myc is a familiy of regulator genes and proto-oncogenes that code for transcription factors which regulates a large number of other pro-proliferative genes. One member of this family, c-myc, is located on chromosome 8 coding for C-MYC that have major regulatory roles in B-cell proliferation. 

Neoplasms

Overexpressed in most Burkitt's lymphoma with certain translocations. Also seen in some DLBCL (single or double hit).

11.02.19 - RR